Статьи и материалы.
Stereotactic neurotransplantation for persistent vegetative state (pvs).
Latyshev D.Yu.,Tsymbaliuk V.I.
Institute of Neurosurgery n. acad. A. Romodanov AMS of Ukraine.
32 Manuilskiy str., Kiev, 04050, Ukrain.
We are presented three patients with PVS who received transplantation cryoconserved embryonic neural cells suspension into the deep brain structures by stereotactic method. The study was approveal by the local Ethics Committee in accordance with the Helsinki Declaration of 2000. The diagnosis of PVS defined by criteria of Multy-Society Task Force on PVS (1994). There is stereotactic sites ventro-lateral thalamus and caput nucleus caudate. There neural graft (NG) is cryoconserved embryonic neural cells suspension, 7-8 weeks gestation, 36,7±11,5?106 cells in 1 ml, lived cells in suspension after recoserved 75%. All patients to had the PVS after atraumatic brain damage. CT and MR imaging defined diffuse cortical and subcortical atrophy. The clinical condition and result of treatment were defined by Rappaport Disability Rating Scale (RDRS) and Rancho Los Amigos levels cognitive function (RCFS). The patients was operated during 2 – 6 month after brain damage. The stereotactics procedure composed 2 patients on one side and 1 patient symmetrically on both sides. In all patient NG introduced it to the lateral ventricle. The volume of transplanted suspension is 1,5 ml intra ventricle and 1,0 ml in to the deep structures. Clinical condition before therapy by RDRS 25±1 score and 2±1 levels RCFS. Over 1 year period all patients had good recovery. One cases RDRS decrease 17 score. In two cases decrease 11 and 13 score. On the RCFS 1 patient had increase on 6 levels, 2 patients – 5 and 4 levels (i.e. minimal conscious state).
Therefore, neural cells reconstruction of brain for patients with PVS is a effective and perspective in future treatment strategy.